Scientists reveal that antibiotics How does the ̵6;last resort’ kill bacteria?
Findings from Imperial College London and the University of Texas may reveal a potential way to make antibiotics more effective.
The colistin antibiotic has become the last resort treatment for some of the most nasty beasts on the planet. However, even when it was discovered 70 years ago, the process by which antibiotics kill bacteria remain a mystery.
Now, researchers have revealed that colistins puncture the bacteria, causing them to pop up like balloons. The work, which was funded by the Medical Research Council and Wellcome Trust, and published in the journal. eLifeIt also identified a way to make the antibiotic more effective at killing bacteria.
Colistin was first described in 1947 and is one of the few antibiotics that are effective against many of the most serious bacteria, including E. coli, which causes bloodstream infections and Pseudomonas aeruginosa and Acinetobacter baumannii, which are often infected Lungs of people receiving ventilators in the intensive care unit
These great have two ‘leather’ called membranes. Colistin penetrates both sides of the membrane, killing bacteria. However, while it is known that colistin destroys the outer membranes by targeting a chemical known as lipopolysaccharide (LPS), but it was not clear whether the inner membrane was penetrated.
Currently, the team led by Dr. Andrew Edwards from the Imperial Department of Infectious Diseases has shown that colistin targets LPS in the inner membranes, although very rare.
Dr. Edwards said: “It sounds clear that colistin destroys both membranes the same way. But it is often assumed that the colistine damages the two membranes in different ways. There is little LPS in the inner membrane, which seems impossible. And we were very skeptical at first.However, by changing the amount of LPS in the inner membranes in the lab and by making chemical modifications, we were able to show that colistin could penetrate both bacterial skin the same way – And this thing kills the villain. “
The team then decided to see if they could use the new information to find a way to make colistin more effective at killing bacteria.
They focus on a bacteria called Pseudomonas aeruginosa, which causes serious lung infections in people with cystic fibrosis. They found that a new experimental antibiotic called murepavadin caused LPS buildup in the bacterial epidermis, making it easier for colistins to penetrate and sterilize.
The team said that because murepavadin is an experimental antibiotic, it cannot yet be routinely used in patients. But clinical trials will begin soon. If these trials are successful, it may be possible to combine murepavadin with colistin to make a potent treatment for a wide range of bacterial infections.
Akshay Sabnis, lead author of the work from the Department of Infectious Diseases, said: “As the global antibiotic resistance crisis continues to accelerate, colistin is increasingly important as it is the last resort of choice. Saving lives of superbugs infected patients By revealing how old antibiotics work, we can devise new ways to kill bacteria more efficiently.
The threat of ‘nightmare bacteria’ resistant to the last colistin antibiotic
Provided by Imperial College London
Reference: Antibiotic ‘last resort’ makes bacteria like balloons (2021, May 4) .Retrieved 4 May 2021 from https://phys.org/news/2021-05-resort-antibiotic-bacteria-balloons.html
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