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Blood oxygen levels could explain why memory loss is an early sign of Alzheimer’s disease.



Blood oxygen levels could explain why memory loss is an early sign of Alzheimer's disease.

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in the world’s first Scientists at the University of Sussex have recorded blood oxygen levels in the hippocampus and have experimented to prove why. which is commonly called The ̵

6;memory center of the brain’ is at risk of damage and degeneration. which is a precursor to Alzheimer’s disease.

To understand why this region is so sensitive, University of Sussex researchers led by Dr. Catherine Hall of the School of Psychology and Sussex Neuroscience studied brain activity and blood flow in the hippocampus of rat The researchers then used simulations to predict whether the amount of oxygen supplied to hippocampal neurons furthest from the blood vessels was enough for the cells to function normally.

Dr. Catherine Hall, Senior Lecturer in Psychology at the University of Sussex, said:

“This discovery is an important step in the search for preventive and treatment measures for Alzheimer’s. Because they suggest that increasing blood flow in the hippocampus can be really effective. in order to prevent damage that occurs

“If that’s right Increasing blood flow in the hippocampus is important to protect the brain from diseases such as Alzheimer’s. It puts weight gain behind the importance of regular exercise and a low-cholesterol diet for long-term brain health.

“We think the hippocampus is in the watershed. normally it’s okay But when something happens to reduce cerebral blood flow. Oxygen levels in the hippocampus drop to a level that stops nerve cells from functioning. We think that may be the first cause of Alzheimer’s disease. memory problems This is because the blood flow is reduced in the early stages, causing the hippocampus to not function properly.

“The same factors that put you at risk for a heart attack make you more prone to dementia. That’s because our brain needs adequate blood flow to provide energy in the form of oxygen and glucose. So brain cells can function properly and Because blood flow can remove waste products such as beta-amyloid proteins that accumulate in Alzheimer’s disease.

“We now want to find out if reduced blood flow and oxygen levels in the hippocampus are causing beta-amyloids to form in Alzheimer’s disease. Understanding what causes damage in the early stages will be crucial in helping us learn how to treat or prevent it.”

Dr. Kira Shaw, a psychology researcher at the University of Sussex. who performed the main experiment said:

“We found that blood flow and oxygen levels in the hippocampus were lower than in the visual cortex. The blood flow and oxygen levels in the visual cortex are greatly increased. which provides energy to hungry neurons but in the hippocampus These responses are much less.”

The scientists also found that the blood vessels in the hippocampus contain less mRNA (code for building proteins) transcripts for vasodilation proteins. In addition, cells that dilate small blood vessels called pericytes differ in shape in hippocampus. hippocampus than in the visual cortex

Dr Shaw concluded: “We think the blood vessels in the hippocampus are less dilate than in the visual cortex.”

research on “Neurovascular coupling and oxygenation were decreased in the hippocampus compared to the neocortex due to differences in microvascular” published in nature communication.


Cannabidiol increases blood flow to the hippocampus.


More information:
K. Shaw et al, Neurovascular coupling and oxygenation are reduced in the hippocampus compared to the neocortex due to differences in microvascular nature communication (2021). doi: 10.1038/s41467-021-23508-y

Provided by the University of Sussex.



reference: Blood oxygen levels could explain why amnesia is an early sign of Alzheimer’s disease (2021, May 28). Retrieved from https://medicalxpress.com/news/2021- 05-blood-oxygen-memory-loss-early on 29 May 2021 html

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