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Coronavirus A ‘double mutant’ found in California.



Stanford scientists have found a worrisome form of the coronavirus first discovered in India, a new, officially unnamed pattern in California.

Nicknamed the “double mutant” variable by the BBC and others, the variable has raised concern among some scientists as it is not a single mutant. But there are two worrisome mutations in the genetic component, which have been identified among other variables, according to the Centers for Disease Control and Prevention.

“We don’t know how the two mutations behave when they̵

7;re paired,” said Dr. Benjamin Pinsky, director of the clinical virology laboratory at Stanford, in an interview when Monday

Pinsky said the existence of the newly discovered variant was first disclosed by the government of India on March 24 after detecting more coronavirus cases in the second-most populous state of Maharashtra. The country with the largest city is Mumbai. The new variant is responsible for approximately 15% to 20% of those infected with the novel coronavirus there.

A day later, on March 25, Stanford lab identified the same variant in coronavirus samples taken from patients in the San Francisco Bay Area.

“On the 25th we got our sequence back and found that ‘Wow, this is the same variable they’re talking about,’ ‘said Pinsky, “so it’s spreading so fast around the world that’s a little impressive and interesting too.”

Why is this new variable so worrisome?

Stanford lab identified one confirmed case of the new variant and seven assumed cases based on samples from patients in the Bay Area, Pinsky said.

No other strain that federal officials examined found to share the two mutations, known as the L452R and E484Q, which are closely related to the known mutations. E484K

The L452R mutation is well known in California as it was found in the California variant (B.1.427 / B.1.429), resulting in strains believed to infect more viral infections and potentially weaken immunity in people. Who have been vaccinated

The E484Q mutation was closely related to the E484K mutation, which was found in the first identified variant in South Africa (B.1.351), Brazil (A1 and A2) and New York (B.1.526). The E484K mutation is also implicated because it may make the virus capable of evading the immune defense response in vaccinated people or survivors of conventional COVID-19.

“What we don’t know are those methods. [two mutations] They work when they’re in the same virus, ”Pinsky said.“ There is a fair amount of information on these. [two mutations] As an individual, would it be worse if we were together We really don’t know how they will respond. ”

Stanford labs routinely perform genetic analyzes for coronavirus samples in COVID-19 patients in the Bay Area. They examined three worrisome mutations: L452R, E484K and N501Y.The N501Y mutation, thought to increase the coronavirus’s ability to spread, was found in a UK variant (B. 1.1.7), as well as a variant of the South African and one of the Brazilian species (P.1).

The Stanford laboratory was able to detect E484Q mutations of the new variant, although the lab was designed to detect only closely related E484K mutations. This can be done, ”Pinsky said.

The variable emphasizes the importance of vaccination.

The emergence of this new variant shows the importance of vaccinating as many people as possible quickly, said Anthony Fauci, the country’s top infectious disease expert, in a briefing last month. already

One way change can be achieved through infection by a single person with a compromised immune system. Rochelle Valensky, director of the Centers for Disease Control and Prevention, said in March.

Coronavirus infection in people with weakened immune systems “can be a breeding ground for many strains, for the simple reason that if you don’t get rid of the virus quickly, you need to be immunologized within the individual.” Viruses can develop in a person to be even stronger.

“That might be the start of this. [New York’s B.1.526 variant]”Fauci said on March 1.

The only way to stop the generation of new strains is to slow down the spread of the virus.

The potential nightmare situation can be the result of various diffusion patterns, just as it is in Brazil. Manaus is one of the hardest hitting cities in the world thanks to the original coronavirus strain, and now it looks like a number of re-infection with the new Brazilian strains. Stephanobertozzi, professor of health policy and dean of the UC Berkeley School of Public Health, said on the UC San Francisco forum last month.

However, the immunity produced by the vaccine is believed to be better than the immunity induced by living COVID-19.

And while some strains are believed to result in a slight decrease in the efficacy of certain vaccines, some experts say the decline equates to only mild to moderate illness.

The currently available vaccines and in development provide 100% protection against death, even in places where there is widespread distribution.

For example, the COVID-19 vaccine made by Johnson & Johnson, Novavax and AstraZeneca has been studied in South Africa and “All of them had decreased efficacy compared to studies in other parts of the world. [the South African B.1.351 variant] Not present, ”Pinsky said.“ However, it is important to note that all vaccines are very effective in preventing severe disease and death. Basically all vaccines are 100% effective right now. ”

“The vaccine manages these variables effectively,” Andy Slavitt, senior adviser to the White House COVID-19 response team, said on Monday.

‘We are worried’

When asked about the new variant, Los Angeles County Health Director Barbara Ferrer said, “We, like everyone else, are concerned”.

“The tool we have for everyone right now is to prevent the infection as much as possible, because it means that strains are not circulating as well,” Ferrer said in a briefing on Monday. The more it is, the more. [that] All variables will be suppressed. “

The UK variant is the most common variant in the US. More than 15,000 cases were reported in all 50 states, both the District of Columbia and Puerto Rico.On the other hand, the South African variant was found in more than 300 and the Brazilian variant P.1 was found in more than 200, and none of these variants were detected in all states.

In California, the two most prominent breeds are the Californian and the UK. The California Department of Health has recorded more than 9,000 cases of the California variant and 851 in the UK. There were 35 cases of Brazilian variant P.1, 33 cases of New York B 1.526, 22 cases of Brazilian variant P.2, and 10 cases of South African variant.

In LA County, strains of South Africa, the United Kingdom and Brazil have been detected. But none of the species dominate the area, Ferrer said.

“We want it to be like that. So let’s do our part: go get vaccinated when it’s our turn, ”she said.

The emergence of the new variant comes as other indicators of the epidemic in California are better than in most countries.

“California now has one of the lowest rates of optimism in the country,” Gov. Gavin Newsom tweeted on Monday. Of all states, California also had the third lowest coronavirus rate per capita during the past week of the country, according to the CDC, with 46 new cases of coronavirus per 100,000 people in the seventh. Days ago Only Oklahoma and Arkansas reported lower rates.

Meanwhile, Michigan had the worst incidence rate in the country, with 452.5 cases per 100,000 people over the past week, followed by New Jersey and New York.

But officials have voiced concerns that the situation in California could worsen if people suddenly decide to stop wearing masks and crowding. Only a third of Californians get at least part of their vaccination.

“Our reality is diverse and growing in cases across the country and around the world, and so is the combination here in LA County. We have to take safety measures. The public health continues until more people are getting vaccinated. If we want to keep our bottom line, ”Ferrer said.

Lin reported from San Francisco, money from Los Angeles.




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