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Coronavirus: US researchers found a strong anti-COVID-19 drug in mice, including different strains.



TORONTO – US researchers have discovered a drug that could be a game-changer in the treatment of COVID-19, including SARS-COV-2.

Researchers in collaboration with the University of Pennsylvania found that diABZI was highly effective in preventing severe COVID-19 symptoms in mice infected with multiple SARS-CoV-2 strains, as described in their article at It was published in Science Immunology on May 18.

The researchers found that SARS-CoV-2 was hidden to avoid stimulation of interferons, a protein that signals the presence of the virus in respiratory epithelial cells. As a result, the immune response is delayed, which in turn causes the virus to infect the respiratory system.

Researchers are trying to find additional immune pathways. They looked at diABZI, which is characterized as STING agonists. STING agonists are drugs that stimulate STING, meant to activate the interferon gene.

The team also considered experiments with cyclic dinucleotides, another type of STING catalyst. However, these drugs have poor availability and low potency compared to diABZI, they said.

The 1

29 rats infected with COVID-19 were treated with diABZI, compared with the control group.The drug-treated mice experienced lower weight loss and lower viral load.

“Certain drugs have been identified as game changers in blocking SARS-CoV-2 infection. This article is the first to show that stimulating the early immune response with the use of “A single drug is a promising strategy for controlling the virus, including South African variant B.1.351,” said Dr. Sara Cherry, senior author of pathology and professor of laboratory medicine at the University of Pennsylvania.

DiABZI is not yet approved by the U.S. Food and Drug Administration or Health Canada, but Sherry said the drug can be effective against other respiratory viruses, such as the common cold and para-influenza virus.

“We are currently testing this STING catalyst against a number of other viruses,” Cherry said. “It is important to remember that SARS-COV-2 will not be the last species of corona we will see and will be protected.”




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