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Covid-19 mutation sparks global concern



The committee normally gathers every three months, but the WHO said the director-general pulled the meeting forward. “To consider issues that need urgent discussion”

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Here are the latest variables and usage considerations. [of] Certificate of vaccination and test for international travel “Organizations around the world said on Wednesday.

The Sars-CoV-2 mutation is raising concern among scientists struggling to find out whether they will respond to the vaccine.

In particular, one of the mutations, first detected in South Africa and in subsequent strains in Brazil and Japan, has caused a stir among researchers studying a variant called 501Y.V2 to determine if. Will the current vaccine be effective?

Experts say the vaccine is likely to remain available for new strains. A confirmation study is ongoing. But those trials take time.

University of Cape Town infectious disease professor Marc Mendelson told ABC News it was not clear whether the South African strain was more contagious. “Studies to date suggest that people infected with this strain have an increased viral load, which tends to increase the person’s ability to transmit to others. Evidence is supported by the speed of the virus.” The increase in infected numbers during the second wave. Both South Africa and the UK have a separate variant with the same mutation at the 501 location in the spike protein. Mendelson, who heads the division of infectious diseases and HIV medicine at Cape Town’s Groote Schuur Hospital, told ABC News.

Mendelson said a lot of urgent work is underway to study the mutations, and he hopes some answers will come within the coming weeks. The most pressing question is, will mutations in the variables affect the vaccine’s response? Then there is the question of whether such variables are related to more serious diseases, I don’t see evidence of that on the ground. (At my hospital), but the subtle differences required a lot of data to be picked up, so that’s little evidence, however, there are currently no signs of a more severe disease. ”

Preliminary studies have found Pfizer’s COVID-19 vaccine appears to be effective against the mutated virus. But more studies are needed because the South African species has a number of additional mutations, including protein changes that disrupt some of the virus.

According to Mendelson, proteins that block not only But it is important for the entry of the virus. But it is also home to man-made antibodies to control viral infections. “Simply put, these antibodies neutralize the virus by binding to a specific sequence of spike proteins, preventing them from binding to receptors in our cells, and preventing their entry if you can prevent them from entering the virus’s cells. You can prevent it from replicating and Another cause of concern is a number of mutations in the viral genetic code in which the variant changes the structure of the inhibitory protein, resulting in reduced binding of cognitive antibodies. The site therefore degrades our immune system’s ability to prevent viruses from entering cells and capturing them. ”

According to the WHO, the South African species has been found in 20 countries, territories and areas after it was first reported to WHO on 18 December.

“Based on the initial and ongoing investigation in South Africa, it is likely that the 501Y.V2 variable is more transmissible than the variable previously spread in South Africa,” the agency’s weekly report said.

On top of that, while this new variant does not seem to cause more serious illnesses. But the rapid increase observed in cases where the numbers put health systems under pressure, ”said the WHO, the geographic distribution of both species is likely to be low.

Fears about the new model’s increased proliferation capacity have led to new locks and additional measures to control COVID-19.

However, the South African strain has raised concern because of an additional mutation that has one scientist named E484K that could make certain vaccines less effective.

The World Health Organization also noted that the new coronavirus The “worrisome” found in Japan requires further investigation.

“The more spread the SARS-CoV-2 virus is, the more likely it is to change. A high level of transmission means that we should expect more spread,” the WHO states. The virus that causes COVID-19 is constantly changing little as it spreads from person to person.

More than 90 million people with COVID-19 have been recorded worldwide since the first case appeared in December 2019.The death toll from the outbreak is close to two million.


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