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Discovery of cancer can help restore nontoxic treatments.



Researchers at the University of Virginia have published a new study that could restore a once-promising treatment to help fight solid cancer tumors, the university announced Monday, the research has been successful as to why immunotherapy. Therapy that targets the ovaries, colon and triple breast Cancer is successfully tested in the laboratory. But it failed in human trials, said lead researcher Jogender Tushir-Singh from the Department of Biochemistry and Molecular Genetics at UVA School of Medicine. Thus, researchers and protein engineers around the world, including our research group, are focused on highly charged tumor cell apoptosis receptors and stimulating the activity of cancer cells. That antibodies in the fight against cancer “At UVA, we use a comprehensive approach to harness the power of the immune system to create duality and clinically effective oncology treatments for the immune system. Solid tumors “

“Our findings also have the potential to significantly improve the clinical efficacy of the current FDA-approved PD-L1
targeting antibodies in solid tumors, especially breast cancer detection. “Milk is three times the negative,” said Tushir-Singh. Selected antibodies to target cancer cells known as death receptor-5 (DR5), the treatment has been successful in past clinical trials by effectively shrinking tumors in animal trials. However, when the treatment reaches human clinical trials, “These antibodies have consistently failed to improve patient survival,” Tushir-Singh and his team found. “Anti-DR5 antibodies approach inadvertently induced biological processes that suppress the body’s immune response,” the university explained in a statement, helping cancer cells avoid treatment and continue to grow.

The research shares findings that can restore the efficacy of the treatment by combating biological processes, which have proven successful in reducing tumor size and improving survival in lab rats. “We would like to see these strategies in clinical trials, which we strongly believe There is a huge potential for solid tumors. “Our findings are unique: In addition to the translation impact, our work also explains that after more than 60 years of research in this field, why are most of our approaches targeting localization? Cell death [cell death] It has not been effective in clinical trials and eventually develops resistance to the treatment. ”




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