Circadian rhythm – The body’s ‘clock’ – regulates our sleep cycle. Whether you are an early riser or a ‘night owl’ is a result of the behavior in which your genes affect your ‘body clock’ when this clock is up, so to speak, the obvious effect is jet lag. Lag is a symptom of a diffused circadian rhythm, etc.
But circadian rhythms, a 24-hour biological process that keep our bodies in sync with the Earth’s rotation, also regulate metabolism, body temperature, hormones, and immune system. On the other hand, many health conditions and diseases show a “circadian component”; and, in some cases, a direct result of an abnormal circadian clock.
In a study published Tuesday in the journal Genome researchScientists report circadian rhythms. Influences the ability to fight many diseases To a greater extent than previously realized This research presents a new understanding of ancient processes and is a clear reminder that “Good sleep hygiene” is too important to your health to feel rested.
Why is it important – Ultimately, research suggests that accurate heart rhythm tracking is key to understanding how the body prevents disease. Changing your sleep routine can dramatically change your health.
Lead author Jennifer Hurley is an assistant professor at the Rensselaer Polytechnic Institute.Her research focuses on the underlying mechanisms of heart rhythm and its impact on human health, she said. inverse Scientists already know that disruption of the circadian clock over life may increase the risk of certain diseases, from cancer to heart disease. However, what is not known is how This interruption leads to increased risks.
“We noticed that all diseases associated with chronic life cycle disruption are also linked to inflammation, which is the product of the immune system,” explains Hurley.
“However, the deep understanding that the immune system clock in a cell or organism does not exist. The objective of this study is to help fill in knowledge gaps. “
What is circadian rhythm?
Every cell in the body has its own biological clock. These tiny timers work together by the central clock in the brain called the nucleus. suprachiasmatic, or SCN, it controls and synchronizes circadian rhythms while keeping everything in time with the Earth’s rotation.Circadian rhythms are found in almost all terrestrial organisms, even plants, are stimulated. Remind to open leaves during the day and close at night.
Circadian rhythms play a role in many processes that are under immunity, and chronic circadian disruption is linked to an increased risk for metabolic, cardiovascular and neurotic diseases. All of these health problems have an inflammatory component, which is why it is hypothesized that abnormal immunization, which can be shown to be chronic inflammation, for example, could be a link between disease and heart rhythm.
Dr. Jennifer Hurley explains her music rhythm research.
The so-called “cogs” of biological clocks are genes and proteins, while macrophages, the white blood cells of the immune system that detect and destroy invasive and harmful organisms such as bacteria, play a key role in the immune system. “The existence and solution instinct of Both acute and chronic inflammation. ”According to the study, the authors argue that macrophages may have a predominant influence on the circadian clock because they live in the bloodstream for several months.
Macrophages, Hurley and her team discovered altered times in response to both pathogens and stress through the regulation of circadian metabolism, but their precise timing nature was totally unexpected, Hurley said.
“We learned that the mechanisms of circadian regulation in cells are more complex than we previously believed, meaning they are more likely to regulate circadian rhythms than we knew,” Hurley said.
“Our studies have great potential for science.”
Drill down to details – To understand this study, Hurley explains that we need to know that the “doctrine of biology” is DNA (our genes) making RNA (transcriptional genes) and proteins (“actors” cells).
“In the field, we made inferences about what circadian clocks do in the body, looking at transcription as a proxy where proteins have circadian rhythms,” Hurley said.
“However, as a protein biochemist, I know a lot of things happen when transcript is made into proteins and looking at just the transcript we miss a lot of what’s going on in the cell.”
The study team examined how macrophage RNA and protein levels changed over two days, finding 80 percent of the circadian protein. No A transcript with circadian rhythms is performed.Later analyzes also revealed the interaction of circadian rhythms and metabolism, primarily the immune function of macrophages, the processes that result from separation. And the merging of mitochondria
The work team also found The protein involved in Covid-19 infection has a circadian rhythm.“It may play a role in the immune response to infection with the virus,” Hurley said.
Can you help with arrhythmia?
According to Hurley: “Of course!”
The number one thing people can do is practice. Good sleep hygieneThis can be divided into three parts:
- Sleep eight hours a night
- Do not let yourself be exposed to bright light at night.
- Maintain a consistent daily schedule so you wake up naturally without the need for an alarm clock.
“The key to all of this is to avoid exposure to bright lights at night, which can interfere with your heart rhythm,” Hurley said. In other words: put down your smartphone or tablet before going to bed at night.
Understanding how the immune system responds to disease is key to finding ways to fight those challenges. Here, the study team found unmissable ways the body works to protect itself from disease, and some of the habits and actions we take could malfunction or strengthen these defense mechanisms.
In the future, Hurley hopes that the study “will help others learn what these new mechanisms are and how they work.”
Abstract: Our main timing mechanism, the circadian clock, plays an important role in building immunity. Although the mechanism of circadian regulation on the immune response is generally explained by the transcriptional or compression stimulation derived from the loop, the negative feedback of transcription translation, research suggests. That certain regulations exist outside of the transcript activity We have provided insights into the transcripts and protease of bone marrow-derived macrophages and found that only 15% of circadian proteases have the corresponding oscillatory mRNA, suggesting that the latter regulation. The transcript affects the regulatory outcome of the macrophage clock to a greater extent than other previously profiled tissues. This regulation may be explained by the powerful mundane value addition we specify for proteins involved in degradation and translation. In addition, extensive post-transcript temporal measurements of metabolic pathways were observed and corresponded to daily changes in ATP production, mitochondrial morphology, and phagocytosis, disruption of regulating regulation. Metabolism after the circadian transcript results in impaired immune function. Our results show that intracellular post-transcriptural regulation is the primary driver of circadian output in macrophages, and this regulation, especially in metabolic pathways, plays a key role in determining. Responds to immune stimuli