Daily intake of large amounts of caffeine may increase the risk of glaucoma by more than three times for people with a genetic predisposition to elevated eye pressure, according to a multicenter international study. Research led by the Icahn School of Medicine at Mount Sinai is the first to demonstrate dietary genetic interactions in glaucoma. The results of the study were published in the June print edition of Ophthalmology It may be recommended that patients with a family history of severe glaucoma should reduce their caffeine consumption.
This study is important because glaucoma is the leading cause of blindness in the United States. The effects of caffeine consumption on glaucoma were studied. and intraocular pressure (IOP), which is the pressure inside the eye. Elevated IOP is a major risk factor for glaucoma, although other factors contribute to this condition. Glaucoma patients often have little or no symptoms until the disease progresses. will progress and loss of vision
“We previously published results suggesting that high caffeine consumption increases the risk of high-tension open-angle glaucoma in people with a family history of the disease. in this study We show that the adverse relationship between high caffeine consumption and glaucoma was clear only among those with the highest genetic risk score for high eye pressure.” Louis R. Pasquale, MD, FARVO, Associate. President of Ophthalmology Mount Sinai Health System Research
The researchers used the UK Biobank, a large population-based biomedical database supported by health and government agencies. They analyzed the records of more than 120,000 participants between 2006 and 2010. Participants were aged 39 to 73 and provided health records along with DNA Samples collected to generate data They answered repeated food questionnaires, focusing on the number of caffeinated beverages they drank daily. The caffeinated foods they eat, specific types, and portion sizes. They also answer questions about their vision, including specifics on whether they have glaucoma or a family history of glaucoma. Three years in the following study, they underwent IOP examinations and eye measurements.
First, researchers looked at the relationship between caffeine consumption, IOP, and self-reported glaucoma using a multivariate analysis. They then assessed whether accounting for genetic information corrected these relationships. They assigned each subject a genetic IOP risk score and analyzed the interactions.
The researchers found that high caffeine consumption was not associated with an increased risk for IOP or a higher overall glaucoma. However, among participants with the strongest genetic predisposition to increased IOP. – In the top 25 percent – higher caffeine consumption was associated with higher IOP and higher prevalence of glaucoma. especially People who consumed the highest daily caffeine intake of more than 480 milligrams, which is approximately four cups of coffee, had an IOP greater than 0.35 mmHg. or about 3 cups of coffee had a 3.9-fold higher prevalence of glaucoma compared to those who didn’t drink the least amount of caffeine and had the lowest genetic risk score group.
“People with glaucoma often ask if they can help protect their vision through lifestyle changes. However, this is an area that has not been studied until now. The study suggests that those at the highest genetic risk for glaucoma may benefit from reducing their caffeine intake. It should be noted that the link between caffeine and glaucoma risk was found only with large amounts of caffeine and in those with the highest genetic risk,” says Anthony Khawaja, MD, PhD, associate professor at the National Institutes of Health. Ophthalmology University College London (UCL) Institute of Ophthalmology and Ophthalmology at Moorfields Eye Hospital “The UK Biobank study helps us learn more than ever how our genes affect glaucoma risk and the role that behavior and our environment can play We look forward to further expanding our knowledge in this area.”
References: “Intraocular pressure, glaucoma, and dietary caffeine consumption – a gene-food interaction study from the UK Biobank” by Jihye Kim, PhD; Hugh Aschard, Ph.D.; Jae H. Kang, ScD; Marleen AH Lentjes, PhD; Ron Doe, Ph.D.; Janey L. Wiggs, MD, PhD; Anthony P. Khawaja, PhD, FRCOphth, and Louis R. Pasquale, MD, on behalf of modifiable risk factors for glaucoma Collaboration, December 14, 2020, Ophthalmology.
The National Eye Institute, part of the National Institutes of Health, and the New York Eye and Ear Infirmary of Mount Sinai helped fund this study.