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High-dimensional characterization of the acute post-acute consequences of COVID-19.



The acute clinical manifestations of COVID-19 are well characterized.1,2; However, the after-acute consequences have not been extensively described. Here, we use the U.S. Department of Veterans Affairs National Healthcare Database to systematic and comprehensively identify six-month incidents, including diagnoses, drug use, and laboratory disorders in 30 survivors. From COVID-19, we show that after the first 30 days of illness, people infected with COVID-19 are at a higher risk of mortality and use of health resources. Our high-dimensional approach identifies a number of respiratory and many other events, including neurological and neurodegenerative disorders, mental health disorders, metabolic disorders, and neurological disorders. Cardiovascular disorders, gastrointestinal disorders, discomfort, fatigue, musculoskeletal pain. We show that a number of treatments are used in increasing cases, including painkillers (opioids and non-opioids), antidepressants, antihypertensive drugs, and oral hypoglycemia, and the evidence. Laboratory abnormalities in various organ systems An analysis of the predetermined results showed an increased risk gradient with the severity of COVID-1

9 infection (untreated, hospitalized and admitted to the hospital). Research shows that in addition to acute illness, COVID-19 survivors face the burden of losing their health. The results provide a roadmap to inform health system planning and the development of a multidisciplinary care strategy to reduce the chronic health loss of COVID-19 survivors.


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