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Researchers reveal important information about how genes are turned on and off.


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The human body has about 30,000 genes that define not only how we look. But also important biological processes Now, a research team at Florida State University and Australian National University have discovered a key aspect of gene regulation and, ultimately, how the process is involved in cancer.

Jonathan Dennis, associate professor of biological sciences at FSU, and David Tremethick, a professor at the Australian National University, have published a new paper in Nature communication That reveals important information about the regulated region of the gene through which proteins attach to turn genes on or off The researchers found that the packaging methods in the region determine how genes are expressed or restricted.

Packaging refers to the full nature of how and where these proteins attach. The process is important for human biology, noted Dennis.

“When the wrong things are bound, you get improper physiology, in some cases cancer,”

; he said.

The new data challenges current models for gene expression methods, revealing that there are many ways promoters can contain to allow or limit gene expression.

A protein called H2A.Z plays a key role in regulating different forms of gene packing. The researchers found that one of the key roles of H2A.Z in gene regulation is to ensure that only appropriate regulatory factors have access to the gene promoter.

“H2A.Z is a type of protein called variable histone,” said Lauren Cole, a former FSU doctoral student and first author of the paper. “Because histone species plays a key role in gene regulation, this work has led to a broader understanding of the human genome.”

Tremethick said the findings underscore the amount of work needed to be done to understand the human genome and how the discovery could move forward.

“Although it has been nearly 20 years since the human genome has been sequenced, But this genome data has been used to select the direct gene expression model that drives decision-making. The fate of the cell is still poorly understood, ”Tremethick said. But our study will help us move forward to better understand how our genes are expressed at the right time and place, having a major impact on human health. ”

DNA structure is involved in genome regulation.

More information:
Lauren Cole et al, Multiple roles of H2A.Z in regulating the architecture of chromatin promoters in human cells, Nature communication (2021). DOI: 10.1038 / s41467-021-22688-x.

Provided by Florida State University

Reference: Researchers reveal key information about gene activation and closure (2021, May 28) .Retrieved May 29, 2021 from https://phys.org/news/2021-05-reveal-key-genes.html.

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