Home / Science / Stem cell release from a dormant state reveals gliogenic domains in the brains of adult mice.

Stem cell release from a dormant state reveals gliogenic domains in the brains of adult mice.



Gliogenesis in the brains of adult rats.

The neural stem cells in the brains of adult rats can produce neurons and glial cells. The exact location of each stem cell can determine the type of neuron the cell produces. and faculty It was shown that neural stem cells also choose the type of glial they produce and when (see View by Baldwin and Silver) injury or selective deletion of the growth factor receptor. Platelet-derived β (PDGFRβ) from stem cells puts them into overload and reveals their selection in relation to glycogenesis. An abnormal type of glial stem cells, which is the progenitor of oligodendrocyte Within the ventricles are located between the cilia of ependymal cells derived from tightly packed PDGFRβ-expressing stem cells.

science, abg8467, this issue, pp. 1

205; See also abj1139, page 1151.

Abstract

Calming neural stem cells (NSCs) in the ventricular-subventricular region of adult mice (V-SVZ) was stimulated to produce some neurons and glia. Here we show that platelet-derived growth factor beta (PDGFRβ) receptors are expressed by V- SVZ NSCs of adults form olfactory bulb and glial interneurons. Selective deletion of PDGFRβ in adult V-SVZ NSCs leads to their release from stasis. revealing gliogenic domains for different types of glial cells. These domains are also selective upon injury. We specify the origin of oligodendrocyte in ventral-derived NSCs within the ventricles exposed to the axon Our findings reveal that the adult V-SVZ has a spatial domain for glyogenesis. In addition to domains for neurogenesis, these gliogenic NSC domains tend to be calmer under homeostasis and may contribute to brain flexibility.


Source link