A recent study conducted by researchers from the Center for Heart Lung Innovation at the University of British Columbia has discovered that the ABO gene, along with other genes, could significantly increase an individual’s chances of developing COVID-19.
Results from the study were presented at the American Thoracic Society 2021 International Conference on Friday.
“By harnessing the power of genome data, we can identify genes associated with COVID-19,” said Ana Hernandez, a postdoctoral fellow at the Center for Heart Lung Innovation. We found that the ABO gene was a significant risk factor for COVID-19, notably the association between ABO blood group and COVID-19 risk. But that’s the cause “
For the study, the researchers used integrative genomics with proteomics to identify genes that may play a role in COVID-19.
The team performed an advance analysis of lung gene expression to identify genetic variables that play a role in the expression in lungs responsible for COVID-19. Blood and a dataset of proteomics obtained from a blood donor.
The results of the study reveal how multiple genes may be responsible for the immune response to COVID-19 and people susceptible to the disease. The genes identified as high-risk for COVID-19 infection are the ABO gene, along with the SLC6A20, ERMP1, FCER1G and CA11 genetic variants.
Many of the genes identified in the study were implicated in other respiratory ailments, including asthma.
“Our research has been running since we did the first analysis. We have now identified some interesting candidates for COVID-19 such as IL10RB, IFNAR2 and OAS1,” Hernandez said. “These genes are linked to the severe COVID-19, their role in the immune response to viral infections, and the evidence indicates that these candidates and their role in COVID-19 should be given to these genes.” Additional checks “