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The rise of coronavirus strains will determine the next phase of the epidemic in the United States.



The bottom line on all three remains positive. In laboratory testing, the vaccine is as effective as the UK-identified strain as the original strain of the virus. And there was only a slight decrease in their efficiency compared to the other two.

“These strains arose as we continue to provide greater opportunities for viral transmission,” said David D. Ho, at Columbia University’s laboratory leading research on the first discovered variant P. 1 in Brazil. “The sooner we vaccinate everyone, the faster we can control the spread of the virus and reduce the likelihood of new breeds.”

But the overall picture hides the problem in some places. At least one strain, causing more severe disease than the original virus, is running through the Northeast and Midwest. That forced officials in some communities to request more vaccines than they would under government population-based formulas. Officials in the Northwest are watching a massive outbreak of the P. 1 strain in British Columbia.

“Right now we need more vaccines here,” said Bruce G. Murphy, Yarmouth, Massachusetts health director in Cape Cod, which has 82 cases. Just 23,000 population

Many vaccination centers in the Boston area do little help for Yarmouth residents, especially the elderly who are unable to travel, Murphy said.

“If we see 13 [cases]That might be just the tip of the iceberg that gets in, ”he said.

Michigan has also requested additional vaccines to curb the surprising increase, as the average daily coronavirus intake rose from 1,503 on March 7 to 7,020 Wednesday, according to CDC data analyzed by The Washington Post.

Asked if the administration would change strategy, Andy Slavitt, a senior adviser to the White House’s coronavirus response team, said on Wednesday the government could move vaccine supplies from other parts of the state to heavily affected areas. Up already

“We were given the amount of vaccine we thought was necessary for the population because that’s fundamental,” Slavitt said. “And then we are working on a tactical area. How to increase vaccination so we get what we need: Efficiency, health equality and other goals that we have “

In addition to the aforementioned three breeds, the CDC looks at two more in California. They are “variables of concern” and are watching them closely. It also examines the variables found in New York City.

As much of the rest of the world is behind vaccination, the virus will continue to spread and mutate every copy with the potential to spark a change that today’s vaccines would have no control over. Experts think the odds are still low. But it is not zero

“I’m afraid that one dreadful variable will come out and bring us back to the square,” Ho said.

But experts say vaccines can be added and new vaccines are being developed to tackle the strains that arise.

As of April 6, there were 16,275 cases of B.1.1.7, 16,275 cases of B.1.1.7 were found in South Africa and 356 cases of P. 1 in the United States. Experts think the real number is much larger. But because of U.S. efforts to delay the viral genome, it is difficult to know how widespread this strain is.

“The landscape is a huge blow for the UK, which is a point of concern in the year. And then there are other strains, too, ”says Daniel Jones, vice president of molecular pathology at Ohio State University Wexner Medical Center. Within weeks, he said, there would be enough infections in the United States to gather better data on the immune response from people than lab tests.

Laboratory tests usually involve looking at the mutations one at a time. Rotating strains can be plentiful, says Stephen Kissler, an immunologist at Harvard T.H. Chan School of Public Health.

And “the human immune system is more complex than we can simulate in a petri dish, so we only get some information,” he said.

Found in more than 24 countries and 25 US states, P. 1 is thought to be 2.2 times more contagious and 61 percent more infectious than the original form of the virus. Which can make people sick

Some experts wonder if competing species slow their spread. For example, Northern California was dominated by B.1.427 / B.1.429 cases, while Southern California had a higher share of B.1.1.7.

“We are seeing different strains in different parts of the country competing for populations,” said Benjamin Pinsky, medical director of the Stanford Clinical Virology Laboratory.

For now, B.1.1.7 seems to stand out. According to the latest data from Helix, the company working with CDC to track the B.1.1.7 variant comprises about 50 percent of all ongoing cases in the United States.

“My feeling is that if you get into the ring with all kinds of breeds, the UK will win in terms of transmission,” said Peter Chin-Hong, an infectious disease specialist at the University of California, San Francisco.

The immune response to P. 1 “is better than the South African variety. But maybe not as good as the British breed, ”Ho said.

The breed, discovered in California, appears to be more gentler than other breeds.Several states with increases in B.1.1.7 have reported unusual outbreaks in school-age children that have spread to their communities. But that’s still not the case for the California variant.

“We have reduced hospitalizations very low,” in areas where B.1.427 / B.1.429 is distinguished, Chin-Hong said. “You expect to see other cases among children and spring breakers. But we haven’t seen that. It shows that it doesn’t mark its territory by making young people sick. ”

In Canada, health workers are struggling with the largest P. 1 variant outside Brazil. There were more than 787 cases in British Columbia as of Tuesday, and a small number. But rose in the adjacent province of Alberta. There was a sick young skier at the Whistler Blackcomb resort and a worker at the twenty-one-player energy company and the Vancouver Canucks’ four-man crew had been infected with a variety of viruses, although the team had not identified it. Which one

Deena Hinshaw, Alberta’s Chief Medical Officer, tweeted Monday that her team is investigating the P. 1 outbreak linked to “big employers” starting with tourists returning from out-of-province trips. She said there was an outbreak in separate workplaces in another part of the state.

Hinshaw said the province had identified 887 new cases in the past 24 hours, and 39 percent of the currently active patients were variable.

In Connecticut, the variant first discovered in the UK helped ages 20 to 29 had the highest incidence rate of all age groups in the state. Whether that reflects the properties of a relaxed precautionary variable among young people, or vaccinations that protect the elderly, or a combination of the three, it remains unclear.

Another species, originally detected in India, made headlines in California this week as This is a “double mutation” due to the characteristics of the species first discovered in California and Brazil / South Africa.

Indian researchers explain on March 24 it was first seen in the United States on March 25 in a patient in the San Francisco Bay Area.

Pinsky said, “It’s too early to tell how this variable will act. We know how these individual mutations change viruses. But we can’t see how they work together. ”

Brazil is now in the occupation of the prime minister. 1 It fully demonstrates how quickly controls can be seized when the action is not taken seriously. In the Amazon rainforest, it quickly devastated the cities it built and then invaded the south. It soon spread across the country and attacks on Brazil, now in the midst of a nationwide medical failure ever since.

Nearly 67,000 Brazilians died of COVID-19, a viral disease in March, more than twice as many as in any other month during the outbreak. The highest deaths were 4,195 as of Tuesday. Scientists have yet to prove that the variables are more dangerous. But doctors and health officials in Brazil say they have signaled a dark and deadly outbreak.

The vaccination rate in Brazil is lagging behind the rate in the United States.

The patient is getting very sick – and much younger.

“Variant species. 1 Across the country is clearly contributing to the increase, ”Sylvain Aldighieri, a senior Pan American Health Organization official, told reporters last week. Higher number “




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