Study of gene activity in the hippocampus Led by researchers from UT Southwestern, they identified clear differences between the anterior and posterior regions of the region. Findings published today in neuronsIt could shed light on a variety of brain disorders associated with the hippocampus and may help lead to new, targeted therapies.
“These new data reveal molecular differences that allow us to view the anterior and posterior hippocampus in a whole new way,”; said Genevieve Konopka, Ph.D., associate professor of neurology at UTSW.
She and co-head of the study Bradley C. Lega, MD, associate professor of neurosurgery, neurology and psychiatry. Explain that, in general, the human hippocampus is considered a homogeneous structure that plays an important role in memory. spatial navigation However, some research suggests that both ends of the hippocampus—the front part pointing down to the face. and the back, which points up behind the head—takes a different role.
Scientists speculate that the anterior hippocampus may be more important for mood and emotions. While the dorsal hippocampus may be more important for perception, however, Konopka, Jon Heighten Scholar in Autism Research, said researchers have yet to explore whether gene activity is different between the two. not
For the study, Konopka and Lega, both members of the Peter O’Donnell Jr. Brain Institute, and their colleagues isolated both anterior and posterior hippocampal samples from five patients whose structures were removed to treat epilepsy. Seizures are usually caused by the hippocampus. Lega, who performed the surgery, explained. Although brain abnormalities provoke these seizures But microscopic analyzes indicated that the tissues used in this study were anatomically normal.
after removal The samples were subjected to single nucleus RNA sequencing (snRNA-seq), which assessed the gene activity in each cell. Although snRNA-seq showed predominantly the same type of neurons, and support cells resided in both parts of the hippocampus, the samples were sequencing. The activity of specific genes in the excitatory neuron—which prompted other neurons to fire—differenced significantly between the anterior and posterior hippocampus . Psychiatry and Nervous System They found an important match. Genes associated with mood disorders, such as depression or bipolar disorder. In the anterior hippocampus, on the other hand, genes associated with cognitive disorders, such as autism spectrum disorders, tended to be more active in the anterior hippocampus. They tend to be more active in the dorsal hippocampus.
Lega noted that the more researchers were able to appreciate these differences, the better. The better they will be able to understand the abnormalities associated with the hippocampus.
“The idea that the anterior and posterior hippocampus represent two different functional structures is not entirely new. But it is not appreciated in clinical medicine,” he said. We must always keep in mind that”
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Fatma Ayhan et al, Solving cellular and molecular polymorphisms along the anterior-posterior axis of the human hippocampal. neurons (2021). doi: 10.1016/j.neuron.2021.05.003
Provided by UT Southwestern Medical Center
reference: Same Difference: Two halves of hippocampus have different gene activity (2021, May 28). Retrieved 29 May 2021 from https://medicalxpress.com/news/2021-05-difference-halves-hippocampus-gene. .html
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