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Why AstraZeneca, J&J Shots Can Cause Blood Clots



  • Scientists say they have discovered how AstraZeneca and Johnson & Johnson’s COVID-19 vaccine causes blood clots.
  • They say the vaccine causes the “mutated” protein to escape cells in the body. stimulates a response in the blood vessels
  • This theory has not been proven or verified by experts. Other theories exist.
  • See more stories on the Business Insider page.

German scientists say they have discovered why the COVID-19 vaccine Some cause abnormal blood clots in some cases.

A team of scientists from Goethe University in Frankfurt, Germany, said on Wednesday that Astrazeneca and Johnson & Johnson’s vaccine delivery mechanism was responsible for the formation of blood clots after chemotherapy. vaccinate

All existing COVID-1

9 vaccines work by delivering the genetic code into the body. This teaches the body to make harmless parts of the virus. which stimulates an immune response The body can show the same reaction if the real virus is later detected.

Vaccines based on mRNA technology, including Pfizer’s and Moderna’s, deliver genetic material to the fluid portion of the cell. Adenovirus-based vaccines such as J&J and AstraZeneca deliver to the central part of the cell called the nucleus, scientists say. The scientists said in the study, which was not reviewed by other experts in a peer review.

according to scientists This is where the problem lies. While the harmless parts of the virus are created in the nucleus. Pieces of genetic material can be broken off. This causes “mutated” proteins that leave cells and travel throughout the body. The walls of blood vessels respond to these proteins, which cause blood clots.

Regulators say abnormal blood clots, especially in the brain, are a rare side effect of both vaccines. for the AstraZeneca vaccine There were 86 cases of atypical thrombosis out of 25 million people vaccinated as of March 22, according to the European Medicines Agency (EMA) for J&J vaccines. There were eight fatal thrombosis reports as of day. On April 13, when more than 7 million people were vaccinated, according to the EMA.

Young women had thrombosis more often than other groups. Scientists suggest that older people are less likely to develop blood clots. This is partly because the immune response is weaker. They added that by nature women have stronger immunity than men.

The theory of the German scientist has not been proven. Researchers at the University of Bristol said in October that the proteins created by vaccines inside human cells reflect precisely the genetic instructions.

Other theories exist. One is that blood cells in the body that cause clotting, called platelets, are “activated” after vaccination and cause blood clots.

Jonathan Ball, a professor of Molecular Virology at the University of Nottingham, told Insider in a statement Thursday that the new research is “the most important thing in the world.” “A really interesting hypothesis.”

The data suggest that protein production disrupts the mutation. “It could happen,” he said.

“But it doesn’t lack a concrete link to the promotion of blood clotting, however, it is certainly worth further investigation,” Ball added.

Rolf Marschalek, a professor at Goethe University who was involved in the research, said they had been in contact with J&J, according to the Financial Times.”[J&J] We are trying to optimize the vaccine right now,” he told the FT.

Marschalek said AstraZeneca had not been contacted.

J&J’s vaccine unit Janssen said in a statement to Insider Thursday: “We continue to support the research and analysis of this rare event as we work with medical professionals and health authorities around the world. We look forward to reviewing and sharing information once it becomes available and at this time we believe it is too early to draw any conclusions.”

An AstraZeneca spokesperson said in a statement to Insider Thursday: “We are working with regulators. Advise agencies and scientific communities around the world to understand more about epidemiology and the possible mechanisms behind these extremely rare events.”


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